Gene

chek1

ID
ZDB-GENE-040426-896
Name
checkpoint kinase 1
Symbol
chek1 Nomenclature History
Previous Names
  • chk1 (1)
  • id:ibd2720
  • zgc:56093
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint; and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in forebrain; hindbrain; immature eye; and midbrain. Orthologous to human CHEK1 (checkpoint kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Sidi et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chek1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Oocyte/zygote/embryo maturation arrest 21 620610
Associated With chek1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR034670 Checkpoint kinase 1, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Checkpoint kinase 1, catalytic domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A8M9PQA7 459
UniProtKB:Q7ZVD7 410
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-chek1 polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations