STRING Network Analysis of the differentially regulated proteins in vtg2-mutant eggs. A total of 83 proteins that were downregulated in vtg2-mutant eggs and 176 proteins that were upregulated in vtg2-mutant eggs were over-represented in specific biological pathways (S2 Table). Each network node (sphere) represents all proteins produced by a single, protein-coding gene locus (splice isoforms or post-translational modifications collapsed). Only nodes representing query proteins are shown. Nodes are named for the transcript(s) to which spectra were mapped; for full protein names, see S1 Table. Edges (colored lines) represent protein–protein associations meant to be specific and meaningful, e.g., proteins jointly contribute to a shared function but do not necessarily physically interact. Protein clusters of similar functions are framed and highlighted with the same colors of functional categories in Fig. 8. Color codes of these categories are given in the bottom left corner of the right panel. Model statistics are presented at the top left and the top right of each panel for proteins down- and up-regulated in mutant eggs, respectively. An explanation of edge colors is given below panels. The subnetwork formed by proteins downregulated in mutant eggs is shown to the upper left above the diagonal dashed line, and the subnetwork formed by proteins upregulated in mutant eggs is shown to the lower right below the diagonal dashed line. Where possible, dashed lines encircle clusters of transcripts encoding interacting proteins involved in physiological processes distinct from other such clusters.
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