Yanchun Yan Lab

The overall goal of our lab is to utilize zebrafish, especially zebrafish embryo, as a basis for the development of (a) mechanistic biomarkers (b) techniques for extrapolation of toxicological effects across endpoints and chemicals, and (c) ecological risk assessments. To achieve this, a combination of whole organism endpoints, transcriptomics and proteomics, approaches is being used to (a) identify new molecular biomarkers of exposure to environmental pollutants,Further research takes advantage of the well characterized zebrafish (Danio rerio) genome, to identify transcriptome and proteome level changes associated with zebrafish exposure to the same suite of environmental pollutants. These data are being used to identify relevant molecular changes that could (a) serve as diagnostic markers for various types of environmental pollutants exposure and (b) begin to inform a systems-level characterization of the responses to those exposures.