| Phenotype: | macrophage apoptotic body accumulation macrophage lysosome, abnormal |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | macrophage |
|---|---|
| Synonyms: | histiocyte |
| Definition: | A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. |
| Ontology: | Anatomy Ontology [ZFA:0009141] |
| Name: | apoptotic body |
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| Synonyms: | apoptotic bleb, apoptotic vesicle |
| Definition: | A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um. |
| Ontology: | GO: Cellular Component [GO:0097189] QuickGO AmiGO |
| Name: | accumulation |
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| Synonyms: | pooled |
| Definition: | A structural quality of the collection or massing of one physical object within another physical object. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002269] |
| Name: | lysosome |
|---|---|
| Synonyms: | |
| Definition: | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| Ontology: | GO: Cellular Component [GO:0005764] QuickGO AmiGO |