| Name: |
broad specificity oxidative DNA demethylase activity |
| Synonyms: |
1-ethyladenine demethylase activity,
2-oxoglutarate-dependent DNA demethylase,
5-formylcytosine dioxygenase activity,
5-hydroxymethylcytosine dioxygenase activity,
N1-methyladenine demethylase activity,
N3-methylcytosine demethylase activity,
oxidative DNA demethylase activity
|
| Definition: |
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. |
| Ontology: |
GO: Molecular Function [GO:0035516]
QuickGO
AmiGO
|
