Search Ontology:
GO: Molecular Function

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Term ID
GO:0008657
Synonyms
  • DNA gyrase inhibitor activity
Definition
Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
negatively regulates
Phenotype
Phenotype caused by Genes