Search Ontology:
GO: Biological Process

I-kappaB phosphorylation

Term ID
GO:0007252
Synonyms
  • IkappaB phosphorylation
  • IKB phosphorylation
  • inhibitor of kappaB phosphorylation
  • inhibitor of NF-kappaB phosphorylation
Definition
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (2)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is part of
has parts
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes