BI-2536

Term ID

CHEBI:49868

Synonyms

• (R)-4-[(8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
• BI 2536
• BI2536

Definition

A member of the class of tetrahydropterins that is 7,8-dihydropteridin-6(5H)-one substituted by {2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino, methyl, ethyl, and cyclopentyl groups at positions 2, 5, 7R, and 8, respectively. It is a polo-like kinase 1 (PLK1) inhibitor with antineoplastic activity.

References

• CAS:755038-02-9
• DrugBank:DB16107
• LINCS:LSM-1041
• PDBeChem:R78
• PMID:17291761
• PMID:20886032
• PMID:21415595
• PMID:22080235
• PMID:22527426
• PMID:22745587
• PMID:23962445
• PMID:24519995
• PMID:25565629
• PMID:26191363
• PMID:28212994
• PMID:28531794
• PMID:28927329
• PMID:29476067
• PMID:31620231
• PMID:32231733
• PMID:33067313
• PMID:33222770
• PMID:35056094
• PMID:35644070
• PMID:36016611
• PMID:36054794
• PMID:36178637
• PMID:37477142
• PMID:37850387
• PMID:38072041
• PMID:38536443
• PMID:38691920

Ontology

ChEBI  ( EBI )