THZ1

Term ID

CHEBI:230500

Synonyms

(E)-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzamide
THZ 1
THZ-1

Definition

A member of the class of indoles that is 1H-indole substituted by a 5-chloro-2-[3-(4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzamido)anilino]pyrimidin-4-yl group at position 3. It is a selective and potent covalent inhibitor of CDK7 that exhibits anti-proliferative effects in cancer cell lines.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyrimidine benzamides enamide indoles organochlorine compound ... Show All 6 Terms

aminopyrimidine benzamides enamide indoles organochlorine compound secondary carboxamide Show first 5 Terms
has_role: antineoplastic agent EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

antineoplastic agent EC 2.7.11.22 (cyclin-dependent kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from THZ1

Phenotype where environments contain THZ1

Phenotype modified by environments containing THZ1

Human Disease / Model Data