Term Name: | NAD-dependent histone deacetylase activity |
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Synonyms: | SIR2 |
Definition: | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. |
Ontology: | GO: Molecular Function [GO:0017136] QuickGO AmiGO |