| ZFIN ID: ZDB-EXP-230331-20 |
Experiment Conditions Description: chemical treatment by environment: imatinib, chemical treatment by environment: eflornithine
| chemical treatment by environment: imatinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | imatinib |
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| Synonyms: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, 4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide, alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide, imatinib, STI 571 |
| Definition: | A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. |
| Ontology: | ChEBI [CHEBI:45783] ( EBI ) |
| chemical treatment by environment: eflornithine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | eflornithine |
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| Synonyms: | 2,5-diamino-2-(difluoromethyl)pentanoic acid, 2-(difluoromethyl)ornithine, alpha-(Difluoromethyl)-DL-ornithine, alpha-difluoromethylornithine, DFMO, DL-Ornithine, 2-(difluoromethyl)-, Eflornithine |
| Definition: | A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. |
| Ontology: | ChEBI [CHEBI:41948] ( EBI ) |
| Publication: | Robertson et al., 2020 |
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