Person
Köster, Reinhard W.
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Biography and Research Interest
Full Professor for Cellular and Molecular Neurobiology
Institute of Zoology
Technische Universität Braunschweig
Associate Professor for Cell Biology and Cell Physiology
Institute of Zoology
Technische Universität Braunschweig
Group Leader/PI of Zebrafish Neuroimaging Group 2003 - 2010
Institute for Developmental Genetics
Helmholtz Zentrum München in Neuherberg/Munich
Postdoctoral Research 1998 - 2003
Biological Imaging Center
California Institute of Technology, Pasadena, USA
Ph.D. Thesis 1995 - 1998
Department of Molecular Developmental Genetics
Max-Planck-Institute of Biophysical Chemistry, Göttingen
Diploma Thesis 1994
Dept. of Physiological Chemistry and Department of Neurology
Julius-Maximilians-University of Würzburg
Study of Organic, Inorganic, 1989-1994
Physical Chemistry and Biochemistry
Julius-Maximilians-University of Würzburg
The Zebrafish Neuroimaging Group aims to understand the molecular mechanisms that govern the migration of neuronal precursors cells in the developing central nervous system. Our focus is on the investigation of the differentiation of the zebrafish cerebellum.
We try to elucidate how migrating neuronal precursors initiate migration, interact with other cells, make pathfinding decisions, stop migration and adopt a specific fate.
As migratory processes are very dependent on their environment cellular behavior is ideally observed directly in vivo. Thus, we employ intravital imaging methods that allow neuronal precursors to be observed continuously as they move, interact with neighbors and respond to altered genetic conditions.
In addition, we are establishing zebrafish models for neurodegenerative diseases of the cerebellum. These models are accessible for in vivo imaging studies and behavioral analysis.
Institute of Zoology
Technische Universität Braunschweig
Associate Professor for Cell Biology and Cell Physiology
Institute of Zoology
Technische Universität Braunschweig
Group Leader/PI of Zebrafish Neuroimaging Group 2003 - 2010
Institute for Developmental Genetics
Helmholtz Zentrum München in Neuherberg/Munich
Postdoctoral Research 1998 - 2003
Biological Imaging Center
California Institute of Technology, Pasadena, USA
Ph.D. Thesis 1995 - 1998
Department of Molecular Developmental Genetics
Max-Planck-Institute of Biophysical Chemistry, Göttingen
Diploma Thesis 1994
Dept. of Physiological Chemistry and Department of Neurology
Julius-Maximilians-University of Würzburg
Study of Organic, Inorganic, 1989-1994
Physical Chemistry and Biochemistry
Julius-Maximilians-University of Würzburg
The Zebrafish Neuroimaging Group aims to understand the molecular mechanisms that govern the migration of neuronal precursors cells in the developing central nervous system. Our focus is on the investigation of the differentiation of the zebrafish cerebellum.
We try to elucidate how migrating neuronal precursors initiate migration, interact with other cells, make pathfinding decisions, stop migration and adopt a specific fate.
As migratory processes are very dependent on their environment cellular behavior is ideally observed directly in vivo. Thus, we employ intravital imaging methods that allow neuronal precursors to be observed continuously as they move, interact with neighbors and respond to altered genetic conditions.
In addition, we are establishing zebrafish models for neurodegenerative diseases of the cerebellum. These models are accessible for in vivo imaging studies and behavioral analysis.
Non-Zebrafish Publications
Loosli, F., K�ster, R.W., Carl, M., Kuhnlein, R., Henrich, T., Mucke, M., Krone, A., and Wittbrodt, J. (2000) A genetic screen for mutations affecting embryonic development in medaka fish (Oryzias latipes). Mech. Dev.. 97(1-2):133-139K�ster, R.W., Kuhnlein, R.P., and Wittbrodt, J. (2000) Ectopic Sox3 activity elicits sensory placode formation. Mech. Dev. 95(1-2):175-187
Loosli, F., K�ster, R.W., Carl, M., Krone, A., and Wittbrodt, J. (1998) Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye. Mech. Dev.. 74(1-2):159-164
K�ster, R.W., Stick, R., Loosli, F., and Wittbrodt, J. (1997) Medaka spalt acts as a target gene of hedgehog signaling. Development. 124(16):3147-3156
R. K�ster, R. G�tz, J. Altschmied, M. Sendtner, M. Schartl (1996). Comparison of monocistronic and bicistronic constructs for neurotrophin transgene and reporter gene expression in fish cells. Molecular Marine Biology and Biotechnology 5: 1-8.
Oliver, G., Loosli, F., K�ster, R.W., Wittbrodt, J., and Gruss, P. (1996) Ectopic lens induction in fish in response to the murine homeobox gene Six3. Mech. Dev.. 60(2):233-239