Person
Brennan, Caroline
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Biography and Research Interest
During development of a vertebrate embryo a series of inductive interactions and cellular rearrangements establish the body plan. One process that is critical for proper organisation of the body is segmentation of the mesoderm. My laboratory is studying cellular and molecular mechanisms underlying segmentation and differentiation of the mesoderm with an emphasis on cell-cell signalling by members of the Eph family of receptor tyrosine kinases and other signalling molecules such as calcium.
Non-Zebrafish Publications
Bell. JD, Barnard. ML, Parkes. HG, Thomas. EL, Brennan. CH, Cunnane. SC, Dagnelie. PC (1996) Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins. J Lipid Res 37(8): 1664-1674.Verhoeven.AJM, Woods.A, Brennan.CH, Hawley.SA, Hardie.DG, Scott.J, Beri.RK, Carling.D. (1995) The AMP-activated protein-kinase gene is highly expressed in rat skeletal-muscle - alternative splicing and tissue distribution of the messenger-RNA European Journal of Biochemistry, 228, (2) : 236-243
Carling.D, Aguan.K, Woods.A, Verhoeven.AJM, Beri.RK, Brennan.CH, Sidebottom.C, Davison.MD, Scott.J (1994). Mammalian amp-activated protein-kinase is homologous to yeast and plant protein-kinases involved in the regulation of carbon metabolism. Journal of Biological Chemistry, 269, (15):11442-11448.
Littleton. J., Brennan. C. (1993) Adaptive changes in numbers of calcium channels in drug dependence. Biochem Soc Symp 50:193-203
Brennan.CH, Littleton.JM. (1991) Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding-sites on cultured bovine adrenal chromaffin cells. Neuropharmacology, 30, (2):199-205
Brennan.CH, Crabbe.J, Littleton.JM.(1990) Genetic-regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical-dependence on alcohol. Neuropharmacology, 29, (5) : 429-432
Brennan.CH, Littleton.JM (1990) 2nd messengers involved in genetic-regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture. Neuropharmacology, 29(7): 689-693
Brennan.CH, Lewis.A, Littleton.JM (1989). Membrane-receptors involved in up-regulation of calcium channels in bovine adrenal chromaffin cells chronically exposed to ethanol Neuropharmacology, 28, (12) :1303-1307
Harper.JC, Brennan.CH, Littleton.JM (1989) Genetic up-regulation of calcium channels in a cellular-model of ethanol dependence. Neuropharmacology, 28 (12) :1299-1302
Brennan.CH,Guppy.L.J., Littleton.JM (1989) Chronic exposure to ethanol increases dihydropyridine-sensitive calcium channels in excitable cells Annals of the New York Academy of Sciences, 560, (JUN):467-469
Littleton. JM, Harper. JC, Brennan. CH, Guppy.LJ. (1988). Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology. Australian Drug and Alcohol Reviews. 7 :35-38
Hudspith.MJ, Brennan.CH, Charles.S, Littleton.JM.(1987) Dihydropyridine-sensitive-Ca2+ -channels and inositol phospholipid- metabolism in ethanol physical-dependence Annals of the New York Academy of Sciences, 492, (.APR):.156-170