Person
Thisse, Christine
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Biography and Research Interest
Research interest : my goal is to understand the molecular mechanisms that control the formation of the early vertebrate embryo. The following questions are currently addressed: how molecular signals from maternal or zygotic origins control the fate of early embryonic cells; how these signals interact with each other to define embryonic germ layers and control their regionalization into organs, tissues and cell types; how molecular signals generate organizer activities that control the initial formation of the embryo. Our long term goal is to identify how naïve, early embryonic blastomeres with stem cell properties can be directed toward the formation of complete tissues and organs in a vertebrate organism.
Representative publications
Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant Proc. Natl. Acad. Sci. USA 108(38):15876-80.
Fauny, J-D., Thisse, B. and Thisse, C. (2009). The entire zebrafish blastula/gastrula margin acts as an organizer dependent on the ratio of Nodal/BMP activity. Development. 136 :3811-3819.
Seiliez, I., Thisse, B. and Thisse, C. (2006) FoxA3 and Goosecoid Promote Anterior Neural Fate through Inhibition of Wnt8a Activity Before the Onset of Gastrulation Dev. Biol. 290, 152-163.
Fürthauer, M., Van Celst, Thisse, C. and Thisse, B (2004). FGF signalling controls the Dorso-Ventral patterning of the zebrafish embryo. Development. 131, 2853-2864
Agathon, A., Thisse, C. and Thisse, B. (2003). The molecular nature of the zebrafish tail organizer. Nature. 424 : 448-452.
Fürthauer, M, Lin, W., Ang, S-L., Thisse, B. and Thisse, C. (2002). Sef acts as a novel feedback induced antagonist of FGF signaling. Nat. Cell Biol. 4, 170-174.
Thisse, B., Wright, C. V. E. and Thisse, C. (2000) Activin and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-427.
Representative publications
Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant Proc. Natl. Acad. Sci. USA 108(38):15876-80.
Fauny, J-D., Thisse, B. and Thisse, C. (2009). The entire zebrafish blastula/gastrula margin acts as an organizer dependent on the ratio of Nodal/BMP activity. Development. 136 :3811-3819.
Seiliez, I., Thisse, B. and Thisse, C. (2006) FoxA3 and Goosecoid Promote Anterior Neural Fate through Inhibition of Wnt8a Activity Before the Onset of Gastrulation Dev. Biol. 290, 152-163.
Fürthauer, M., Van Celst, Thisse, C. and Thisse, B (2004). FGF signalling controls the Dorso-Ventral patterning of the zebrafish embryo. Development. 131, 2853-2864
Agathon, A., Thisse, C. and Thisse, B. (2003). The molecular nature of the zebrafish tail organizer. Nature. 424 : 448-452.
Fürthauer, M, Lin, W., Ang, S-L., Thisse, B. and Thisse, C. (2002). Sef acts as a novel feedback induced antagonist of FGF signaling. Nat. Cell Biol. 4, 170-174.
Thisse, B., Wright, C. V. E. and Thisse, C. (2000) Activin and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-427.
Non-Zebrafish Publications
Thisse, C. and Thisse, B. (1992). Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators. Development Suppl. 173-181. Thisse, C., Perrin-Schmitt, F., Stoetzel, C. and Thisse, B. (1991). Sequence specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell. 65 : 1191-1201.
Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P. and Perrin-Schmitt, F. (1991). The M-twist gene of Mus is expressed in subset of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol. 143 : 363-373.
Thisse, B., Stoetzel, C., Gorostiza-Thisse, C. and Perrin-Schmitt, F. (1988). Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J. 7 : 2175 - 2183.