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Fig. 1

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ZDB-IMAGE-230920-9
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Figures for Verwilligen et al., 2023
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Fig. 1

Fig. 1. SCARB1 deficiency in zebrafish is linked to reduced fertility. (A) Percentage of zebrafish that are WT, heterozygous (HZ) or knock-out (KO)(of total laid eggs) after crossing scarb1+/− fish (n = 5 individual scarb1+/− crossings). (B) Representative pictures of adult females and their tails (scarb1 715delA and scarb1 715_716insGG homozygous and sibling controls) at 3 months post-fertilization. (C) Total fertilized egg count at 0 h post fertilization (hpf) produced by WT or scarb1−/− breeding pairs (nWT = 15 breeding pairs, n-1nt = 16 breeding pairs, n+2nt = 9 breeding pairs). (D) Percentage of survival from 0 hpf till 3 days post fertilization (dpf) of WT and scarb1−/− zebrafish larvae. (E) Representative picture of the development of scarb1−/− embryo's compared to WT embryo's at 0 till 3 dpf. (F) Total fertilized egg count at 0 h post fertilization (hpf) produced by outcrosses (♀ WT × ♂ WT (n = 15 breeding pairs), ♀ WT × ♂ scarb1−/− (n = 5 breeding pairs), ♀ scarb1−/− × ♂ WT (n = 8 breeding pairs), ♀ scarb1−/− × ♂ scarb1−/− (n = 25 breeding pairs)). Means ± SEM; p < 0.05*, p < 0.001*** (One-way ANOVA (multiple groups) or Student's t-test).

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Reprinted from Biochimica et biophysica acta. Molecular and cell biology of lipids, 1868(6), Verwilligen, R.A.F., Mulder, L., Araújo, P.M., Carneiro, M., Bussmann, J., Hoekstra, M., Van Eck, M., Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions, 159308, Copyright (2023) with permission from Elsevier. Full text @ BBA Molecular and Cell Biology of Lipids