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Fig. 5
Graphical abstract of CLEC16A interaction with retromer and TRIM27. Left panel shows normal interaction of CLEC16A with early endosome, retromer, and TRIM27. Under physiological conditions, CLEC16A protects from autophagy and regulates mitophagy. Right panel: C-terminus truncated CLEC16A loses interaction with early endosomes, hereby increasing TRIM27 binding to early endosome and F-actin polymerization. CLEC16A dysfunction leads to dysregulated autophagy and accumulation of unhealthy mitochondria
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Full text @ Hum. Genet.