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Fig. 1
Zebrafish mitfa;tfec mutants phenocopy human colobomas. (A) At 4 dpf, mitfa−/−;tfec−/− mutants possess colobomas (outlined in red), with a range of severity (B). (C) At 48 hpf, serial sections through the distal (D) to proximal (P) axis of the CF reveal persistent expression of laminin in the mitfa−/−;tfec−/− mutant CF. The boxes indicate the areas enlarged in the insets showing laminin staining within the CF. Dorsal is upwards in all images. Scale bars: 50 µm.
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