ZFIN Image: Sinagoga et al., 2020, Fig. 2

Image

Figure Caption

Fig. 2

mitfa−/−;tfec−/− mutants display RPE and cNCC phenotypes. (A) At 48 hpf, mitf−/−;tfec+−/− and mitfa−/−;tfec−/− mutants display mild to severe hypopigmentation, respectively. The RPE eventually becomes normally pigmented by 4 dpf in both genotypes. (B) At 24 hpf, fewer cNCCs are present around the eye of mitfa−/−;tfec−/−;mitfa:GFP embryos than in the control (1) (***P=0.0007). However, mitfa−/−;tfec−/− mutants contain cNCCs posterior to the optic field (2). (C) Serial sections of mitfa−/−;tfec+/+;mitfa:GFP and mitfa−/−;tfec−/−;mitfa:GFP embryos at 48 hpf demonstrate that mitfa−/−;tfec−/− mutants possess fewer cNCCs in the POM surrounding the eyes. Dorsal is upwards in the images in B,C. Data are mean±s.e.m. Scale bars: 100 μm in A; 50 μm in B,C.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development