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Fig. 8
Asymmetric expression of elovl6 requires Nodal signaling but does not depend on Pitx2. (A,B) Analysis of asymmetric pitx2c (A) or elovl6 (B) expression (arrows) at the 18 somite stage (ss) in control embryos and embryos treated with SB-505124 to block Nodal signaling. The graphs indicate the percentage of embryos with normal left-sided expression or absent expression. (C) Asymmetric elovl6 expression (arrows) in wild-type and pitx2HD mutant embryos. n=number of embryos analyzed.
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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.