ZFIN Image: Jazwinska et al., 2007, Fig. 2

Image

Figure Caption

Fig. 2 Inhibition of ActβA Signaling Blocks Zebrafish Fin Regeneration with the Serrate Phenotype (A and B) Fins shortly after amputation. n = 4. The scale bar in (A) represents 200 μm. (C and D) After 3 hpa, the epidermis covered the wound. The interrays acquired indentations along the amputation plane, as indicated by arrows in both control (C) and Alk4-i-treated fins (D). (E and F) At 6 hpa, the interray gap closure occurs in control fins (E) but is suppressed in the presence of the inhibitor (arrows in [F]). (G and H) After 10 dpa, the control fins completed regeneration (G), whereas the fins treated with the inhibitor did not regenerate and displayed the serrate phenotype, as seen in the inset (H). The red line in (G) marks the amputation plane.

Acknowledgments

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