Gene

fancm

ID
ZDB-GENE-090929-1
Name
FA complementation group M
Symbol
fancm Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have 3'-5' DNA helicase activity; four-way junction DNA binding activity; and four-way junction helicase activity. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing; interstrand cross-link repair; and replication fork reversal. Human ortholog(s) of this gene implicated in male infertility and premature ovarian failure. Is expressed in central nervous system; eye; and lens. Orthologous to human FANCM (FA complementation group M).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Titus et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fancm Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ovarian insufficiency 15 Alliance Premature ovarian failure 15 618096
spermatogenic failure 28 Alliance Spermatogenic failure 28 618086
Associated With fancm Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001650 Helicase, C-terminal domain-like
Domain IPR006166 ERCC4 domain
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR031879 Fanconi anemia group M protein, MHF binding domain
Domain IPR039686 FANCM/Mph1-like, insert domain
Domain IPR044749 FANCM, DEAH-box helicase domain
Domain IPR047418 Fanconi anemia group M protein, XPF-like nuclease domain
Homologous_superfamily IPR010994 RuvA domain 2-like
Homologous_superfamily IPR011335 Restriction endonuclease type II-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length DEAD/DEAH box helicase domain ERCC4 domain FANCM, DEAH-box helicase domain FANCM/Mph1-like, insert domain Fanconi anemia group M protein, MHF binding domain Fanconi anemia group M protein, XPF-like nuclease domain Helicase, C-terminal domain-like Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase Restriction endonuclease type II-like RuvA domain 2-like
UniProtKB:A8QLH8 1761
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations