Gene
lgi1b
- ID
- ZDB-GENE-060217-1
- Name
- leucine-rich, glioma inactivated 1b
- Symbol
- lgi1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Involved in brain morphogenesis and myelination. Predicted to localize to extracellular region. Is expressed in brain; eye; head mesenchyme; heart; and skeletal muscle. Human ortholog(s) of this gene implicated in childhood absence epilepsy and familial temporal lobe epilepsy 1. Orthologous to several human genes including LGI1 (leucine rich glioma inactivated 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Teng et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial temporal lobe epilepsy 1 | Alliance | Epilepsy, familial temporal lobe, 1 | 600512 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
Family | IPR051295 | Leucine-rich glioma-inactivated/LGI-related |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Repeat | IPR001611 | Leucine-rich repeat |
Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Repeat | IPR005492 | Leucine-rich glioma-inactivated , EPTP repeat |
Repeat | IPR009039 | EAR |
Domain Details Per Protein
Protein | Length | Cysteine-rich flanking region, C-terminal | EAR | Leucine-rich glioma-inactivated , EPTP repeat | Leucine-rich glioma-inactivated/LGI-related | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
---|---|---|---|---|---|---|---|---|
UniProtKB:B3DJS9
|
543 | |||||||
UniProtKB:F1R662
|
543 |
Interactions and Pathways
No data available
Plasmids
No data available