Gene
kif1b
- ID
- ZDB-GENE-030820-1
- Name
- kinesin family member 1B
- Symbol
- kif1b Nomenclature History
- Previous Names
-
- unm st43
- unm_st43
- wu:fb74c11
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including axon extension; neuron projection maintenance; and posterior lateral line system development. Predicted to localize to axon; dendrite; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Is expressed in nervous system and neurons. Orthologous to human KIF1B (kinesin family member 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2A1 | Alliance | Charcot-Marie-Tooth disease, type 2A1 | 118210 |
| {Neuroblastoma, susceptibility to, 1} | 256700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR000253 | Forkhead-associated (FHA) domain |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR022140 | Kinesin-like KIF1-type |
| Domain | IPR022164 | Kinesin-like |
| Domain | IPR032405 | Kinesin-associated |
| Domain | IPR049780 | Kinesin-like protein KIF1A/B, pleckstrin homology domain |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead-associated (FHA) domain | Kinesin-associated | Kinesin-like | Kinesin-like KIF1-type | Kinesin-like protein KIF1A/B, pleckstrin homology domain | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase | SMAD/FHA domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PKM3
|
1795 | ||||||||||||
|
UniProtKB:A0A8M3AMT9
|
1918 | ||||||||||||
|
UniProtKB:A0A8M3AMV0
|
1232 | ||||||||||||
|
UniProtKB:A0A8M3ANK4
|
1848 | ||||||||||||
|
UniProtKB:A0A8M3AMU4
|
1882 | ||||||||||||
|
UniProtKB:F1QJ64
|
1161 | ||||||||||||
|
UniProtKB:A0A8M3ANK1
|
1910 | ||||||||||||
|
UniProtKB:A0A8M3AVA2
|
1809 | ||||||||||||
|
UniProtKB:A0A8M3AMU7
|
1783 | ||||||||||||
|
UniProtKB:A0A8M3B624
|
1857 | ||||||||||||
|
UniProtKB:A0A8M3AYC4
|
1761 | ||||||||||||
|
UniProtKB:F1QBV5
|
1770 | ||||||||||||
|
UniProtKB:A0A8M3B629
|
1769 | ||||||||||||
|
UniProtKB:A0A8M3AYB6
|
1901 | ||||||||||||
|
UniProtKB:A0A8M9PEY4
|
1913 | ||||||||||||
|
UniProtKB:A0A8M6Z4D8
|
1798 | ||||||||||||
|
UniProtKB:A0A8M2B951
|
1147 | ||||||||||||
|
UniProtKB:A0A8M3AV93
|
1924 | ||||||||||||
|
UniProtKB:A0A8M3B621
|
1915 | ||||||||||||
|
UniProtKB:A0A8M3AYB9
|
1840 | ||||||||||||
|
UniProtKB:E9QDE5
|
1763 | ||||||||||||
|
UniProtKB:A0A8M3AVA7
|
1679 | ||||||||||||
|
UniProtKB:A0A8M3AV98
|
1887 | ||||||||||||
|
UniProtKB:A0A8M3ANL2
|
1685 |
Interactions and Pathways
No data available
Plasmids
No data available