Gene
agk
- ID
- ZDB-GENE-030131-6202
- Name
- acylglycerol kinase
- Symbol
- agk Nomenclature History
- Previous Names
-
- fi38e09
- mulk
- wu:fi38e09
- zgc:55462 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have kinase activity. Predicted to be involved in phosphorylation; protein insertion into mitochondrial inner membrane; and sphingolipid biosynthetic process. Predicted to localize to TIM22 mitochondrial import inner membrane insertion complex; integral component of mitochondrial inner membrane; and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55462 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cataract 38 | Alliance | Cataract 38, autosomal recessive | 614691 |
Sengers syndrome | Alliance | Sengers syndrome | 212350 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
Domain | IPR045579 | Acylglycerol kinase, C-terminal |
Family | IPR050187 | Lipid Phosphate Formation and Regulation |
Homologous_superfamily | IPR016064 | NAD kinase/diacylglycerol kinase-like domain superfamily |
Homologous_superfamily | IPR017438 | Inorganic polyphosphate/ATP-NAD kinase, N-terminal |
Domain Details Per Protein
Protein | Length | Acylglycerol kinase, C-terminal | Diacylglycerol kinase, catalytic domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | Lipid Phosphate Formation and Regulation | NAD kinase/diacylglycerol kinase-like domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q7ZW00
|
422 |
Interactions and Pathways
No data available
Plasmids
No data available