FIGURE

Figure 3

ID

ZDB-FIG-231030-75

Publication

Toualbi et al., 2023 - Gene Augmentation of CHM Using Non-Viral Episomal Vectors in Models of Choroideremia

Other Figures

All Figure Page

Back to All Figure Page

Figure 3

Micro-injection of chm^ru848 zebrafish with pS/MAR-CHM. Wholemount color and fluorescent images of (A) wild-type, (B) chm^ru848, (C) pS/MAR-CMV-CHM-injected wild-type, and (D) pS/MAR-CMV-CHM-injected chm^ru848 zebrafish at 5 days post-fertilization. (E) Comparison of survival in injected and un-injected chm^ru848 zebrafish larvae. (F) Western blot for human-specific REP1 protein with the 2F1 antibody in injected and un-injected chm^ru848 zebrafish larvae. Human REP1 was detected in the injected zebrafish only. (G) Prenylation assay to detect levels of un-prenylated Rabs in wild-type, injected, and un-injected chm^ru848 zebrafish larvae (* = p < 0.05; *** = p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848 (AB)
Observed In:	ball eye lens pericardium retina swim bladder whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.